At the fourth round of the 2022 Monster Energy AMA Supercross Championship, the Anaheim 2 Supercross, Honda HRC’s Ken Roczen quickly got into the lead ahead of Rocky Mountain ATV/MC-KTM-WPS’ Shane McElrath and Rockstar Energy Husqvarna’s Malcolm Stewart. Monster Energy Kawasaki's Jason Anderson as chasing down Roczen and the two made contact in the sand section, sending Roczen to the ground. (Anderson later said it was bad judgment on his part and apologized). Anderson made a mistake overjumping into the elevated turn before the whoops, which allowed Monster Energy/Star Yamaha Racing’s Eli Tomac to sneak to the inside and into the lead. Tomac would go on to lead the remainder of the race and take the checkered flag, his first win of the season as he became the fourth different rider to win in the first four rounds. Anderson finished second and Honda HRC’s Chase Sexton made several passes to eventually claim the final spot on the podium. Tomac, Sexton, and Anderson remain the top three in the points standings.

In the 250SX Class, SmarTop/Bullfrog Spas/MotoConcepts Honda’s Vince Friese grabbed the holeshot. But Troy Lee Designs/Red Bull/GasGas Factory Racing’s Michael Mosiman quickly made his way to the lead. Mosiman held off Monster Energy/Star Yamaha Racing's Christian Craig for the majority of the race until the veteran rider got around his younger competitor. Mosiman kept Craig honest throughout the remainder of the race but eventually Craig took the race win, his third of the season. Friese was in the final podium position until a crash in the whoops late in the whoops ended his night early. Honda HRC’s Hunter Lawrence claimed the final spot on the podium.